We furthermore noted that at baseline and at a steady state ≥14 days after FCM exposure, EMVs from patients with HF displayed a generally lower CD62E+/CD31+ and CD54+/CD144+ ratio than EMVs from healthy subjects, indicating a higher degree of endothelial apoptosis in HF patients and supporting the concept of dysfunctional endothelium in HF patients. Here, CDH5 is linked to hydrops fetalis.