Subsequently, extracting RNA sequencing data from EEC samples in TCGA, we constructed a signature of ORGs including ANG, SULT1A2, DGAT2, YIPF1, SRGAP3, LRRC31, FMOD, OR6B2, DHRS7B, and FAM222B. ANG-encoding proteins belong to the ribonuclease A superfamily and have been widely reported to be associated with the invasion and progression of various cancers. The gene discussed is FAM222B; the disease is cancer.