While cadherin, a key molecule for tumor entry into blood vessels and lymph, is associated with tumor infiltration and metastasis by mediating EMT (41, 42).Our study suggested that high expression of H3C1 and IGFBP1 predicted poor prognosis, while CDHR4 was a prognostic protective factor (Figure 1H), consistent with the results of the currently published studies. This evidence concerns the gene IGFBP1 and neoplasm.