In Figure 4B, overexpression of COL10A1 enhances the proliferation, migration, and invasion of CRC cells (Huang et al., 2018); MMP11 expression affects the immune response in CRC (Buttacavoli et al., 2021); ADAM12 may play vital roles in the recruitment of immune cells in CRC (Huang et al., 2021); and COMP promotes CRC cell proliferation partially through the activation of the PI3K/Akt/mTOR/p70S6K pathway (Liu et al., 2018). This evidence concerns the gene ADAM12 and colorectal carcinoma.