The relevance of looping formation and genomic organization together with the identification of architectural proteins associated with boundaries might shed light on the functional and mechanistic implications in different diseases, as demonstrated in these seminal works focused on neurological disorders and cancer (Bharadwaj et al., 2014; Weischenfeldt et al., 2017; Zhu et al., 2020). This evidence concerns the gene PROS1 and nervous system disorder.