In 2012, 3C was used to identify physical interaction between the chromosome region 16p13, often associated with increased risk for a plethora of autoimmune diseases, including multiple sclerosis (Zuvich et al., 2011), primary biliary cirrhosis (Mells et al., 2011) and systemic lupus erythematosus (SLE) (Gateva et al., 2009), with DEXI (dexamethasone-induced protein), a gene with previous unknown function, revealed as a strong candidate for autoimmune disease (Davison et al., 2012). The gene discussed is DEXI; the disease is systemic lupus erythematosus.