Polygonatum sibiricum saponin could decrease the abundance of Firmicutes in T2DM rats and increase the abundance of Bacteroidetes; thereby, it could significantly decrease the levels of insulin secretion and fasting blood glucose (FBG), TG, TC, and low-density lipoprotein cholesterol (LDL-C) and increase the content of high-density lipoprotein cholesterol (HDL-C) (35). The gene discussed is INS; the disease is type 2 diabetes mellitus.