Other studies have shown that TNK treatment significantly decreased fasting serum insulin (FINS) and FBG; increased the insulin sensitivity index (ISI); improved impaired glucose tolerance; reduced the serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-Δ (TNF-Δ); and increased serum adiponectin in SHR rats (68). This evidence concerns the gene IL6 and Impaired glucose tolerance.