In addition, the intermediate expression profile of the two tumours between NF1 and DLST mutated PPGLs, the DLST-like methylation profile observed for one of them, and the accumulation of cis-aconitate and the heterogeneous 5-hmC staining observed in the other tumour, reinforces a role of the DLST mutation in tumour molecular characteristics. Here, NF1 is linked to neoplasm.