The number of café-au-lait macules has been found to be influenced by common SNPs (32), polymorphisms in ADCY8 correlate with glioma risk in a sex-specific manner (33), and rare germline variants in various genes including ATM have been proposed as candidate modifiers of plexiform neurofibroma (34). The gene discussed is ADCY8; the disease is Cafe-au-lait spot.