Hierarchical clustering of the two tumours carrying dual mutations in NF1 and DLST based on expression data for genes differentially expressed in DLST-mutated PPGLs grouped them in between DLST and NF1 mutated PPGLs, suggesting that an intermediate phenotype was caused by the coexistence of the two alterations (Figure 2D). The gene discussed is NF1; the disease is neoplasm.