NF1 and neoplasm: It has been reported that the methylation profile observed in DLST-mutated tumours is intermediate between the CpG island methylator phenotype (CIMP) described for SDH-mutated PPGLs and the unmethylated profile exhibited by tumours belonging to the so called cluster 2 (i.e. tumours with mutations in NF1, RET, MAX or HRAS) (24).