For example, resveratrol, a SIRT1 activator, reduces cell death in animal models of neurotoxin-induced PD (Lofrumento et al., 2014); SIRT2 inhibitors rescue α-syn-mediated PD toxicity in cell models (Outeiro et al., 2007; Singh et al., 2019). This evidence concerns the gene SIRT2 and Parkinson disease.