Although FABP4 has been less studied in PD, previous studies suggest that FABP4 is a powerful and novel biomarker for acute stroke (Bacigaluppi and Martino, 2020), an effective target for diabetes treatment (Cao et al., 2013), a predictor of adverse cardiovascular events (Peeters et al., 2011), a key determinant of the metastatic potential of ovarian cancer (Gharpure et al., 2018) and a regulator of neuroinflammation and cognitive decline in obese mice (So et al., 2022), which indicates that further studies of SIRT4 in the field of PD are warranted. Here, SIRT4 is linked to Parkinson disease.