Since ER stress/UPR pathway is involved in asthma development (Miao et al., 2020) and TNFα activates this pathway in several cell types (Xue et al., 2005; Denis et al., 2010; Yap et al., 2020b; Zhao et al., 2021), we investigated whether TNFα activates ER stress/UPR pathway in primary human lung fibroblasts and whether asthmatic lung fibroblasts have dysregulated responses. The gene discussed is TNF; the disease is asthma.