INS and type 2 diabetes mellitus: Calorie deficit resulting in weight loss has a positive effect on glucose tolerance (Norris et al., 2005; Schenk et al., 2009), and intensive lifestyle interventions with focus on behavior, nutrition and activity, have shown superior weight loss and larger improvements in insulin sensitivity in patients with both T2DM and who are overweight/obese, compared with Diabetes Education and Support (self-management) (Pi-Sunyer, 2014).