The Huh7, HepG2, PLC/PRF5, Hep3B, SNU 368, SNU 387, and SNU 449 HCC cell lines and HBV replicating HepG2.2.15 and HepAD38 cell lines revealed a higher expression of PIN1 and PIN4 proteins (Figure 1B). This evidence concerns the gene PIN4 and hepatocellular carcinoma.