In the context of neurodegenerative diseases, a study by Yao et al. demonstrated that miRNA-124 could inhibit neuroinflammation in the development of PD by regulating the MEKK3/NF-κB signaling pathways and implicated miRNA-124 as a potential therapeutic target of holding the inflammatory response in PD [218]. This evidence concerns the gene MAP3K3 and Parkinson disease.