NFKB1 and Parkinson disease: Ultimately, α-Syn-induced microglial activation promotes α-Syn phagocytosis via microglial FcγR receptor and subsequently results in a series of proinflammatory events such as NF-κB (p65) nuclear translocation leading to an elevated release of cytokines, potentiating the loss of DA neurons and chronic neurodegeneration in PD [231].