As shown in Figure 6, Pik3c2a, Akt1, eNOS, Hspa8, Dnajal, and Arntl were downregulated, and Dbp, Rasd1, Ugt1a1, and Aldh1a3 were upregulated in the PHT group compared to the controls. Here, AKT1 is linked to pulmonary hypertension, primary, 1.