As shown in Figure 6, Pik3c2a, Akt1, eNOS, Hspa8, Dnajal, and Arntl were downregulated, and Dbp, Rasd1, Ugt1a1, and Aldh1a3 were upregulated in the PHT group compared to the controls. Here, HSPA8 is linked to pulmonary hypertension, primary, 1.