As shown in Figure 6, Pik3c2a, Akt1, eNOS, Hspa8, Dnajal, and Arntl were downregulated, and Dbp, Rasd1, Ugt1a1, and Aldh1a3 were upregulated in the PHT group compared to the controls. The gene discussed is BMAL1; the disease is pulmonary hypertension, primary, 1.