Although both models use different statistical techniques, they comprise a multiple analysis of maternal history and biomarkers such as uterine artery Doppler (UtA), placental growth factor (PlGF), and blood pressure, which have demonstrated better detection rates compared to maternal history alone (5, 7), however, biomarkers are still far from being robust enough to adequately discriminate those women developing preeclampsia, mainly due to the lack of robust methodology in their measurement and analysis (8). The gene discussed is PGF; the disease is preeclampsia.