Given the protective function of MCUb in the heart (Lambert et al., 2019; Huo et al., 2020) and the detrimental role of mitochondrial Ca2+ overload in neurons (Mattson et al., 2008; Briston et al., 2019; Jung et al., 2020; Modesti et al., 2021), it is logical to predict that MCUb plays neuroprotective roles in stroke and neurodegenerative diseases. Here, MCUB is linked to Stroke.