MCUB and type 2 diabetes mellitus: In contrast to these findings, MCUb is upregulated in a type 2 diabetic mouse heart, and the introduction of a dominant-negative MCUb transgene into the type 2 diabetes mouse model reversed the cardiac defects, as well as the metabolic aspect of the phenotype suggesting detrimental effects of MCUb expression in this model (Cividini et al., 2021).