The heart-enriched lncRNA Chaer (cardiac hypertrophy-associated epigenetic regulator) binds EZH2 with a 524 nt secondary structure similar to that of Fendrr (Wang et al., 2016); however, differently from Fendrr, it prevents PRC2 binding to chromatin, thereby decreasing the levels of H3K27me3 at the target genes. The gene discussed is FENDRR; the disease is cardiac hypertrophy.