DNMT1 and hepatocellular carcinoma: GIHCG is aberrantly upregulated in hepatocellular carcinoma (HCC), where it recruits both PRC2 and DNA methyltransferase 1 (DNMT1) on the promoter of miR-200b/a/429, a microRNA (miRNA) often epigenetically dysregulated in cancer (Wiklund et al., 2011), causing an increase in H3K27me3 and DNA methylation (DNAme) and therefore silencing the locus (Suijun et al., 2016).