Another circRNA, FECR1, is able to simultaneously recruit TET1 and repress DNMT1 to decrease the methylation levels of the oncogene Friend leukemia virus integration 1 (FLI1), aberrantly overexpressed in various tumors, promoting metastasis in breast cancer (Chen et al., 2018) (Figure 3B). Here, FLI1 is linked to breast carcinoma.