GIHCG is aberrantly upregulated in hepatocellular carcinoma (HCC), where it recruits both PRC2 and DNA methyltransferase 1 (DNMT1) on the promoter of miR-200b/a/429, a microRNA (miRNA) often epigenetically dysregulated in cancer (Wiklund et al., 2011), causing an increase in H3K27me3 and DNA methylation (DNAme) and therefore silencing the locus (Suijun et al., 2016). Here, GIHCG is linked to hepatocellular carcinoma.