In addition, IL-5 stimulates the production and secretion of T15/EO6 IgM via the TI-2 immune response of innate B-1 cells, and T15/EO6 IgM can inhibit the uptake of ox-LDL by macrophages, thus playing a protective role in the development of atherosclerosis [12, 25]. Here, CD40LG is linked to atherosclerosis.