However, many non-infectious conditions such as allergies and autoimmune diseases can dramatically influence CRP and ESR values (Giacomelli et al., 2018; Davis and van der Hilst, 2018; Aringer, 2020), whereas PCT does not change significantly in some Gram-positive bacterial and fungal infections or local infections (Ito and Ishida, 2020; Xu et al., 2021). This evidence concerns the gene CRP and autoimmune disease.