Previously, using the same non‐food allergic infant DNA methylation data, we found that naive CD4T cells from infants with egg allergy exhibit diminished lymphoproliferative responses following non‐specific activation with anti‐CD3 and anti‐CD28, reflected at the molecular level by impaired expression of T cell activation genes, and epigenetic remodeling at genes linked to metabolic pathways.6 This evidence concerns the gene CD28 and egg allergy.