The results showed that the age between the two groups (χ2 = 14.075, P < 0.001), whether menopause (χ2 = 8.140) There are differences in P = 0.017), AR (χ2 = 6.848, P = 0.033), chemotherapy (χ2 = 7.512, P = 0.006), and at menarche age, whether there is a family history of breast cancer, BMI, TNM staging, tumor There were no significant differences in size, presence or absence of lymph node metastasis, expression of ER and PR, Ki-67, Her-2, pathological classification, and whether or not surgery. The gene discussed is ESR1; the disease is breast cancer.