There were no significant differences in age, menopause, menmene age, family history of breast cancer, BM, TNM stage, tumor size, lymph node metastasis, ER and PR expression, Ki-67, Her-2 gene expression, AR and pathological typing..There were 43 cases in the VitB5 (< 32.47 ng/ml) group and 44 cases in the VitB5 (≥ 32.47 ng/ml) group. The gene discussed is ESR1; the disease is breast cancer.