The M2 TAMs targeting peptide, CRV (amino acid sequence, CRVLRSGSC), was overexpressed on the exosomes by fusing CRV sequence into lysosome-associated membrane glycoprotein 2b (Lamp2b) encoded plasmids, which were packaged with lentivirus and transfected in the lung cancer cell line. The gene discussed is TREX1; the disease is lung carcinoma.