They also found that thinner choroid was associated with a lower estimated glomerular filtration rate (eGFR) and, in CKD, with proteinuria as well as increased circulating C-reactive protein, interleukin 6 (IL-6), asymmetric dimethylarginine (ADMA), and endothelin-1 (ET-1). The gene discussed is CRP; the disease is chronic kidney disease.