As shown in Fig. 7a, the low STON1 group manifested an intensive effect of anti-cancer immunity activities, especially priming and activation, the recruiting of B cells, CD8 T cells, dendritic cells, macrophages, myeloid derived suppressor cells (MDSCs), neutrophils, NK cells, T cells, and Th1 cells, and the recognition of cancer cells by T cells. Here, CD8A is linked to cancer.