Regarding individual immune regulators, correlations with TAP1 in each cancer were highly significantly positive or negative; specifically, LAG3, ICOS, HAVCR2, CD80, PDCD1, IDO1, PDCD1LG2, TIGIT, CD274, CD86, and TNFRSF9 exhibited markedly stronger correlations than other ICPs. This evidence concerns the gene ICOS and cancer.