THBS1 and Stroke: While CD36 acts as a co-receptor for TLR heterodimers and CD36/TLR2 signalling mediates injury in adult and neonatal stroke it also recognizes a plethora of ligands, such as low-density lipoprotein, long-chain fatty acids, thrombospondin-1, fibrillar β-amyloid (Aβ), and the cell membrane proteins of apoptotic cells9,29–31.