INSR and Insulin resistance: A second cluster comprised 172 proteins with higher abundance in AdEVs from lean mice (Fig. 2c, cluster 2): ADIPOQ, GPC4 and TUSC5 (Fig. 2e) are negatively correlated to body weight and likely protective against insulin resistance; INSR, ABHD15, SLC27A1, CALM1, SNTB2) are mediators of insulin signaling, and MRC1, CD163, CLEC10a are anti-inflammatory22–26.