TLR4 and obesity due to melanocortin 4 receptor deficiency: Cluster 1 included the obesity-related adipokines LEP17 and RBP418 (Fig. 2d), proteins associated with inflammatory reactions to overnutrition (ITGAL, IKBIP), MHC class II members (H2-AA, H2-K1, H2-D1) and inflammatory TLR4 signaling members (TAP2 and CD180)19–21.