Flow cytometry data also verified that T-αFGL2 treatment, compared with T-Ctr, increased the proportion of CXCR3+CD69+CD8+ T cells among total CD8+ T cells in glioma-bearing brains (Fig. 8b), indicating that increased CXCR3 expression on CD8+ T cells may play a role in T cell recruitment and in mediating T-αFGL2-induced CD69+CD8+ TRM cell formation. Here, CD8A is linked to central nervous system cancer.