LRRK2 and Parkinson disease: In the LRRK2 locus, three previously reported risk variants, rs34594498 (LRRK2-A419V), rs33949390 (LRRK2-R1628P), and rs34778348 (LRRK2-G2385R), were found to be independently associated with PD with suggestive significance (P < 1×10−5) (Fig. 3).