KEGG analysis indicated that the up-regulated DEGs in EAC were primarily enriched in Pertussis, IL-17 signaling pathway, cytokine-cytokine receptor interaction, ECM-receptor interaction, protein digestion and absorption, and Amoebiasis (Fig. 2C); while the down-regulated genes in EAC were enriched in chemical carcinogenesis, Amoebiasis, drug metabolism-other enzymes, steroid hormone biosynthesis, bile secretion, glycerophospholipid metabolism, and inflammatory mediator regulation of trp channels (Fig. 2D). Here, IL17A is linked to pertussis.