However, the CD274 haplotype rs822335*C-rs10815225*G-rs17718883*C-rs2297136*A-rs4143815*G-rs4742098*A (reference haplotype: rs822335*C-rs10815225*G-rs17718883*C-rs2297136*G-rs4143815*G-rs4742098*A) might decrease the age at diagnosis of NSCLC on average by 1 year and 5 months after adjustment for smoking (Parameter =  − 1.51; 95% CI =  − 2.73, − 0.28; P = 0.016) (Supplementary Table S15). Here, CD274 is linked to non-small cell lung carcinoma.