Comorbid neurodegenerative disease was present in 25 of the 68 CTE cases (36.8%) including AD, Lewy body disease (LBD), frontotemporal lobar degeneration (FTLD)-TAR DNA-binding protein (TDP), progressive supranuclear palsy (PSP) and Pick’s disease. The gene discussed is TARDBP; the disease is neurodegenerative disease.