Among those diagnosed with CTE, the spectrum of p-tau pathology ranged in severity from sparse perivascular foci of NFTs in the cortex, usually the frontal cortex, to a severe, widespread tauopathy affecting the medial temporal lobe, thalamus, hypothalamus, mammillary bodies, basal ganglia, brainstem, cerebellum, and white matter tracts. The gene discussed is MAPT; the disease is tauopathy.