TARDBP and nevus comedonicus syndrome: Although TDP-43 pathology in CTE bears some similarities to limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC), it was recently recommended that the diagnosis of LATE-NC be avoided in CTE cases until future studies determine whether TDP-43 pathology in CTE is unique to CTE or a manifestation of early-onset LATE-NC [86].