Among the two ChREBP isoforms (ChREBPα and ChREBPβ; both encoded by the Mlxipl gene) [37], the 100 kDa protein band corresponding to ChREBPα [35] was found to be significantly increased in the refed state and after 2, 4 and 8 weeks of HCD, but decreased after 22 weeks of chronic HCD (Fig. 6a,b). Here, MLXIPL is linked to heavy chain disease.