TCF7L2 and fatty liver disease: Indeed, miR-33-5p reduced Tcf7l2 deficiency-induced expression and function of Srebf1c. On the other hand, although miR-132-3p and miR-212-3p (other miRs that can cause Srebf1c mRNA decay [40, 41]) were decreased in primary hepatocytes and the liver of hepatic Tcf7l2-deficient mice, and reduced Srebf1 3′UTR luciferase activity, they did not inhibit the expression and function of Srebf1c. These data suggest that miR-33-5p is an important factor for regulating the expression and function of Srebf1c in hepatic Tcf7l2 deficiency-induced liver steatosis.