Moreover, the mTOR antagonist rapamycin regulates vascular remodeling and blood-brain barrier leakage after status epilepticus (van Vliet et al., 2012, 2016a, b), indicating that a physiological function of the mTOR pathway (i.e., in the absence of any mutations) is to regulate the blood-brain barrier. The gene discussed is MTOR; the disease is status epilepticus.