HDLBP and Albright hereditary osteodystrophy: Furthermore, vigilin has been shown to be associated with autism and brachymetaphalangy, where 2q37 deletion syndrome results in downregulation of vigilin and causes the Albright hereditary osteodystrophy-like phenotype, characterized by developmental delay, mental retardation, and brachymetaphalangy (26, 27).