Depletion or mutations in genes encoding RBPs like TDP-43 (TAR DNA-binding protein 43), FUS (fused in sarcoma), and FMRP (fragile X mental retardation protein) leads to human neurological disorders such as spinal muscular atrophy, amyotrophic lateral sclerosis, and fragile X syndrome (16). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.