For the diagnosis of LADA, the Immunology of Diabetes Society [14] proposed the following criteria: age of onset over 30 years; the presence of at least one type of anti-pancreatic islet antibody (glutamic acid decarboxylase autoantibodies -GADAs, anti-GAD or GADAb-, insulin autoantibodies -IAA-, protein tyrosine phosphatase IA-2 -IA-2A-, islet-specific zinc transporter isoform 8 -ZnT8- autoantibodies), and insulin independence the first six months after diagnosis of the disease. The gene discussed is INS; the disease is diabetes mellitus.