Interestingly several variants were observed exclusively in patients with invasive ductal carcinoma (NST/NOS) and these included a missense variant each in MT-ND1 (A3434G), MT-ND2 (G4491A), MT-TD (T7581C), MT-CO2 (G7859A), MT-ND3 (G10143A) (S5 Table). The gene discussed is MT-ND1; the disease is invasive ductal breast carcinoma.