The clinical data were as follows: Of 229 patients, 62 (27.1%) were > 65 years old, 163 (71.2%) were male, 79 (34.5%) had AFP > 20 ng/ml, 224 (97.8%) were Child Pugh class A, 123 (53.7%) were hepatitis B surface antigen (HBsAg) positive, 86 (37.6%) were anti-HCV positive, and 8 (3.5%) were alcohol abusers. This evidence concerns the gene AFP and alcohol drinking.