To further analyze the role of cholesterol metabolism in poor prognosis of COVID-19 we evaluate retrospectively the parameters of cholesterol metabolism (plasma lipids concentrations and exomere fraction, the expression levels of LDLR activity pathway genes selected through our previous transcriptome analysis) as well as cytokine profile as possible predictors of fatal outcome in patients with severe COVID-19 infected by the Alpha and the Delta variants of SARS-CoV-2 virus. Here, LDLR is linked to COVID-19.