De Miranda JA et al. [22] and Ingelsson E et al. [23] consistently found that NOS3 label SNPs rs3918188 and rs7830 are not associated with hypertension in children and adolescents, and that rs3918186, rs3918188, rs753482, rs891512, rs1808593, rs7830 are not associated with endothelium-dependent vasodilation, which is similar to our results to a certain extent. This evidence concerns the gene NOS3 and hypertensive disorder.