Thus, together we show LRRC15 is expressed specifically by lung fibroblasts, is found coating the airways in COVID-19 patients, and mechanistically, LRRC15 can act to sequester SASR-CoV-2 virus and help suppress infection, which may potentially help protect ACE2+ alveolar epithelium in patients with COVID-19. This evidence concerns the gene LRRC15 and infection.