CXCL12 and head and neck cancer: In naïve CD8+ T-cells, dopamine (10−7M) potentiated homing to CCL19, CCL21, and CXCL12 through D3 and Gαi-mediated Ca2+ mobilization (Watanabe et al., 2006), and treating peripheral T-cells from head and neck cancer patients with dopamine (10−8M) increased spontaneous migration and migration toward CXCL12 (Saussez et al., 2014).