Interestingly, reactive glia have been shown to contribute to inflammatory responses in the GI through activation of NF-κB pathways in both mouse models of dextran sulfate sodium–induced colitis (Esposito et al., 2014; MacEachern et al., 2015) and humans with ulcerative colitis (Cirillo et al., 2011; Esposito et al., 2014). Here, NFKB1 is linked to colitis.