Rotigotine (D2-like agonist) reduced TNF-α production and NF-κB activation in a mouse model of acute liver injury (Yue et al., 2021), and D2 signaling inhibited NF-κB activation by inhibiting Akt in a murine model of acute pancreatitis (Han et al., 2017). This evidence concerns the gene NFKB1 and acute pancreatitis.