Pathways in Cancer obtained from KEGG included the Wnt, Hedgehog, Notch, HIF-1, cAMP, mTOR, PI3K-Akt, Jak-STAT, MAPK, Calcium, TGF-β, VEGF, p53, and PPAR signaling pathways, and none of these pathways showed significant changes as the CR level was increased (Supplementary Figure 21). This evidence concerns the gene TP53 and cancer.