Thus, we constructed a coculture system containing THP-1–derived M0 cells and fibroblasts (NF or KF) and found the expression of p-STAT6 and TGF-β in M0 cells was upregulated when cocultured with KFs .TGF-β was regarded as the key regulator of keloid fibrogenesis (Figure 1E). This evidence concerns the gene TGFB1 and keloid.