Consistent with our previous finding that KFs drove p-STAT6 activation of THP-1 cells, we speculated that a possible positive feedback loop exists between KFs and profibrotic M2-like macrophages in keloid fibrogenesis via the IL-13/STAT6 axis and the deficient IL-13RA2 expression of KFs, which warrants further investigation. Here, STAT6 is linked to keloid.