PI4K2B and lung cancer: To test this hypothesis, we initially queried The Cancer Genome Atlas (TCGA) lung cancer cohort and found that an EMT-associated gene expression signature was positively correlated with PI4K2A levels, whereas other PI4K family members were either negatively correlated (PI4KB, PI4K2B) or not correlated (PI4KA) with EMT (Figure 1A).