The levels of the Golgi-resident scaffolding protein acyl coenzyme A binding domain–containing 3 (ACBD3), which tethers PI4KB to Golgi membranes (27), were higher in epithelial cells than in mesenchymal cells, were negatively correlated with ZEB1 levels in the Cancer Cell Line Encyclopedia (CCLE) (Figure 2A and Supplemental Figure 2, A and B), and were coordinately regulated in ZEB1 gain- and loss-of-function studies (Figure 2, B and C, and Supplemental Figure 1C). Here, PI4KB is linked to cancer.