Given that PI4K2A’s prognostic impact in non–small cell lung cancer (NSCLC) is histologic subtype specific, we assessed the biological role of PI4K2A in cell lines isolated from diverse NSCLC subtypes, including LUSC (CALU-1), large cell carcinoma (H1299), and LUAD (A549, H441, HCC827). The gene discussed is PI4K2A; the disease is lung cancer.