TP53 and neoplasm: The neuropathological examination confirmed presence of a somatotroph pituitary neuroendocrine tumor (along with strong hormonal expression, sparse granulation, globular expression of Cam.5.2, fibrous bodies in more than 70% of tumor cells, Ki67 ranging from 5 to 10% in some hotspots, and strongly expressed p53 in 5% of the cells; Pit-1 was positive, whereas T-pit and SF-1 were negative) (Fig. 2).