For example, SAMD9‐overexpression suppresses non‐small cell lung cancer progression,[4] while it promotes disease progression in glioblastoma.[5] Importantly, a report has shown that SAMD9 is upregulated in primary tumors of ESCC patients with metastasis compared to no metastasis,[6] suggesting that SAMD9 may be involved in promoting ESCC metastasis. This evidence concerns the gene SAMD9 and lung cancer.