According to a report by Lin et al., abnormal GSK3β degradation caused hyperactivation of the Wnt/β‐catenin pathway stimulates MYH9 expression by increasing c‐Jun expression in hepatocellular carcinoma.[9] Here, we demonstrate that SAMD9 stimulates the expression of MYH9 and c‐Jun, and activates the β‐catenin pathway by downregulating GSK3β in ESCC. The gene discussed is SAMD9; the disease is hepatocellular carcinoma.