Myosin‐9 (YH9) is a non‐muscle myosin heavy chain IIA involved in the regulation of cell migration.[7] Studies have shown that MYH9 is aberrantly upregulated and it enhances cancer stemness in gastric[8] and liver cancers.[9] Importantly, cancer stemness is a crucial factor for cancer metastatic recurrence.[10] Upregulated MYH9 expression and its correlation with metastasis in ESCC was reported previously.[11] These findings suggest that MYH9 might promote ESCC metastasis by enhancing cancer stemness, but whether MYH9 promotes ESCC progression through cancer stemness has not been reported. This evidence concerns the gene MYH9 and liver cancer.