According to a report by Lin et al., abnormal GSK3β degradation caused hyperactivation of the Wnt/β‐catenin pathway stimulates MYH9 expression by increasing c‐Jun expression in hepatocellular carcinoma.[9] Here, we demonstrate that SAMD9 stimulates the expression of MYH9 and c‐Jun, and activates the β‐catenin pathway by downregulating GSK3β in ESCC. This evidence concerns the gene MYH9 and esophageal squamous cell carcinoma.