Furthermore, there were elevated expression levels of lncMEG3, p53, SFRP1, and E‐cadherin, and downregulated expression levels of miR‐542‐3p, p‐GSK‐3β, β‐catenin, N‐cadherin, Vimentin and Snail in tumor tissues of mice upon MTE treatment, and the tendencies were reversed in mice treated with both MTE and sh‐MEG3 (Figure 10A,B). This evidence concerns the gene MEG3 and neoplasm.