Furthermore, p53 protein and EMT‐related proteins E‐cadherin, N‐cadherin, Vimentin, and Snail in glioma cells were tested, and the corresponding results revealed that MTE treatment resulted in increased expression levels of E‐cadherin and p53 and decreased expression levels of N‐cadherin, Vimentin, and Snail, and that further transfection of sh‐MEG3 could offset the MTE treatment‐mediated effects on the expression levels of these proteins (Figure 3C). The gene discussed is CDH1; the disease is central nervous system cancer.