The csHR of BW change associated with dementia was no longer significant after adjustment for apolipoprotein E genotype and baseline cognitive function in the fully adjusted model (both of which were significantly associated with risk of dementia), which was likely affected by the reduction in sample size due to a larger number of missing values for apolipoprotein E genotype (n = 30) and baseline cognitive function (n = 25). The gene discussed is APOE; the disease is dementia.