AGT and age-related macular degeneration: In the model of proliferative Diabetic Retinopathy (DR) and Age-Related Macular Degeneration (AMD), Ang II upregulates the secretion of angiogenic factors and growth factors, provokes microglial activation and leads to hypertension (Moravski et al., 2000; Shi et al., 2010; Hatzopoulos et al., 2014).