At the early stage of retinopathy, the CD39 expression is significantly up-regulated to maintain the balance between ATP and ADO; when retinal disease develops in the advanced stage, the number of CD39+ microglia decrease prominently and the balance between ATP and ADO is broken; The overladen ATP in the retinal microenvironment mediate inflammatory reaction that leads to neuronal death and M1 microglial activation (Lu et al., 2015; Hu et al., 2017; Rodrigues-Neves et al., 2018). The gene discussed is ENTPD1; the disease is retinal disorder.