In both the discovery and replication cohort, all four proteins were increased in PMS patients in comparison to healthy controls (CCL3: Pdis < 0.001, Prep < 0.001; IL-12B: Pdis < 0.001, Prep < 0.05; IL-8: Pdis < 0.001, Prep < 0.001 and CXCL10: Pdis < 0.001, Prep < 0.01). This evidence concerns the gene CXCL10 and premenstrual tension.