Significantly increased levels of IL-8 have been observed in a variety of inflammatory and autoimmune conditions, but it is also important for trafficking of leukocytes to the CNS.21,34,35 In difference to IL-12B, IL-8 does not seem to reflect acute inflammation in the CNS.21 IL-8 concentration was increased in the CSF from multiple sclerosis patients in several studies,21,36,37 and has also been linked to a worse prognosis. The gene discussed is IL12B; the disease is multiple sclerosis.