Comparable results were observed for the correlating proteins (TNFRSF9, sCD5, MCP-2, CXCL11, CXCL1, all P < 0.001–P < 0.01), except for sCD5, MCP-2 and TNFRSF9, where the difference between PMS patients and healthy controls in the replication cohort was not significant (Supplementary Table 1 and Fig. 1). The gene discussed is SCD5; the disease is premenstrual tension.